Thaum Lub Yim Hli 16, 2021, travere kev kho mob tshaj tawm tias sparsentan, tshuaj nyob hauv kev tshawb fawb rau kev kho IgA nephropathy (IgAN), tau txais cov txiaj ntsig zoo ua ntej ib ntus hauv qhov tseem ceeb theem 3 kev sim tshuaj tiv thaiv. Tom qab 36 lub lim tiam ntawm kev kho mob, kev txo qis ntawm cov proteinuria hauv pab pawg sparsentan piv nrog cov hauv paus tau ntau dua peb zaug uas nyob hauv pawg tswj hwm nquag (P< 0.0001).="" hais="" txog="" kev="" nyab="" xeeb,="" sparsentan="" feem="" ntau="" zam="" tau="" zoo,="" zoo="" ib="" yam="" nrog="" cov="" yam="" ntxwv="" kev="" nyab="" xeeb="" tau="" pom="" txog="" tam="" sim="" no.="" raws="" li="" cov="" txiaj="" ntsig="" ntawm="" kev="" tshuaj="" xyuas="" ib="" ntus,="" lub="" tuam="" txhab="" npaj="" yuav="" siv="" txoj="" kev="" pom="" zoo="" nrawm="" los="" xa="" daim="" ntawv="" thov="" tshuaj="" tshiab="" nyob="" rau="" thawj="" ib="" nrab="" ntawm="">
Sparcentan yog endothelin / angiotensin receptor antagonist (deara) nrog ob lub tswv yim. Cov ntaub ntawv ua ntej qhia pom tias nws tuaj yeem txo cov proteinuria, tiv thaiv podocytes thiab tiv thaiv glomerulosclerosis thiab mesangial cell proliferation los ntawm kev thaiv hom 1 txoj hauv kev ntawm endothelin A thiab angiotensin II. IgA nephropathy yog kab mob raum tsis tshua muaj, uas feem ntau ua rau mob raum kawg. Hauv ntau yam kab mob hauv lub raum (xws li IgA nephropathy), kev sib xyaw ntawm endothelin receptor thiab angiotensin receptor blocker, angiotensin hloov pauv enzyme inhibitor lossis renin angiotensin blocker muaj zog kho tau zoo ntawm cov proteinuria.
404 tus neeg laus IgAN cov neeg mob tau cuv npe tsis tu ncua, ob-qhov muag tsis pom, sib koom ua ke, tswj kev ua haujlwm thiab ntau lub tsev kho mob sim tshuaj tiv thaiv. Cov neeg mob no txuas ntxiv txhim kho cov proteinuria txawm tias siv tshuaj kho mob zoo. Hauv kev sim, cov neeg mob tau txais kev kho mob ib ntus nrog 400 mg sparsentan ib hnub ib zaug lossis cov tshuaj tswj hwm hauv qhov sib piv ntawm 1: 1. Tom qab 36 lub lis piam, cov proteinuria ntawm pab pawg sparsentan (n=280) poob los ntawm 49.8% thiab cov pab pawg tswj hwm tau txo qis 15.1% (P<>
Kev txheeb xyuas ua ntej ntawm cov txiaj ntsig kev nyab xeeb rau lub sijhawm nruab nrab pom tias tam sim no, ob pawg kev kho mob feem ntau tau ua zoo nyob hauv txoj kev tshawb fawb, sparsentan zoo ib yam nrog cov yam ntxwv kev nyab xeeb yav tas los, thiab tsis muaj cov cim tshiab txog kev nyab xeeb.
Sparcentan tseem tab tom ua qhov tseem ceeb theem 3 kev sim tshuaj kho mob focal segmental glomerulosclerosis (FSGS). Kev tshaj tawm xov xwm tau taw qhia tias yog ob qho kev qhia pom zoo, sparsentan yuav yog thawj qhov tshuaj pom zoo rau FSGS thiab IgAN tib lub sijhawm.
