Nature Reviews Microbiology tau tshaj tawm tsab xov xwm tshuaj xyuas tshiab "modulating tiv thaiv kab mob raws li kev kho mob rau cov kab mob" los ntawm Canadian cov kws tshawb fawb. Hauv tsab xov xwm, tus sau tau piav qhia txog qhov kev nce qib tshiab hauv kev tswj hwm lub cev tiv thaiv kab mob raws li kev kho mob rau cov kab mob. Cov kws tshawb fawb tau pom tias kev tiv thaiv kab mob tsim nyog ntawm lub cev cov lus teb raws li kev xav tau yog kev kho mob zoo, xws li tiv thaiv kab mob ntawm cov kab mob pathogenic, inhibiting autoimmune thiab inflammatory reactions, thiab ua rau cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm cov neeg mob uas ua rau mob qog noj ntshav.
Tam sim no, muaj kev kho mob immunomodulatory feem ntau yog siv los tiv thaiv kab mob. Cov kws tshawb fawb feem ntau siv cov tshuaj tiv thaiv kab mob hauv lub cev los kho cov kab mob tiv thaiv kab mob hauv lub cev, thiab lawv kuj siv cov kev kho mob ntxiv los ua kom cov tshuaj tua kab mob ntev ntev los yog cov tshuaj tiv thaiv kab mob, xws li interferon lossis tshuaj tiv thaiv kab mob; Qhov tseem ceeb tshaj plaws yog kev tiv thaiv kab mob, uas tuaj yeem txhim kho kev tiv thaiv kab mob ntawm tib neeg lub cev. Hauv tsab xov xwm no, tus sau feem ntau qhia txog kev kho mob adjuvant thiab tshuaj tiv thaiv adjuvant; Therapeutic adjuvants, hu ua immunomodulators, tuaj yeem txhim kho lub cev tsis muaj zog tiv thaiv kab mob. Kev kho immunomodulatory muab kev yooj yim rau peb. Peb tuaj yeem coj lub cev ua lub hom phiaj es tsis yog cov kab mob pathogenic. Immunomodulatory tuaj yeem zam qhov kev xaiv siab los ntawm kev hloov pauv ntawm cov kab mob tshuaj tiv thaiv mus rau qhov loj tshaj.
Nyob rau lub sijhawm ntev, qhov tshwm sim uas hloov kev tiv thaiv kab mob yog qhib los ntawm cov tshuaj tiv thaiv tseem yuav rov zoo. Tsis tas li ntawd, cov tshuaj tiv thaiv tsis muaj dab tsi tshwj xeeb hauv lub cev tiv thaiv kab mob muab rau peb qee cov lus qhia tias cov kev hloov kho lub cev yuav tsum muaj peev xwm ua tau ntau yam kev tiv thaiv ntau yam kab mob, tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv ntawm cov neeg muaj kev pheej hmoo siab thiab kev txheeb xyuas thiab kev kho mob thaum ntxov. kis kab mob. Txawm li cas los xij, qhov tsis tsim nyog hauv lub cev tiv thaiv kab mob yuav ua rau lub cev ua ntej cov lus teb thiab cov ntaub so ntswg puas. Yog li ntawd, kev vam meej immunomodulatory txoj kev kho yuav tsum tau tswj lub stimulation ntawm lub cev tiv thaiv kab mob es tsis ua rau kom lub cev lub pre-inflammatory tiv thaiv teb.
Cov kws sau ntawv tau hais tias qhov kev tshawb pom ntawm cov tshuaj tua kab mob nyob deb dhau ntawm qhov kev tiv thaiv microbial. Yog li ntawd, tiam tshiab ntawm immunomodulatory kev kho mob rau cov kab mob sib kis tau coj cov kev cov nyom loj thiab kho muaj peev xwm rau tib neeg noj qab haus huv. Hancock thiab lwm tus tsuas yog ntsuas lub peev xwm ntawm kev ua kom lub cev tiv thaiv kab mob tiv thaiv kab mob los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev, Cov tshuaj tiv thaiv kab mob no suav nrog cov qauv lees paub receptor tsev neeg agonists (PRRS), tus tswv tsev tiv thaiv kab mob tiv thaiv peptides (HDPs, tseem hu ua antimicrobial peptides), thiab natural bacterial ligands.
