Cov qog ua haujlwm rau apoptosis thiab kev tiv thaiv kab mob qog noj ntshav microenvironment yog ob qho laj thawj tseem ceeb rau kev kho qog tsis zoo. Pyrosis yog ib txoj hauv kev soluble thiab inflammatory programmed cell tuag txawv ntawm apoptosis. Cov pov thawj tseeb qhia tau hais tias qhov induction ntawm pyrosis nyob rau hauv cov qog hlwb ua rau muaj zog inflammatory teb thiab tseem ceeb qog regression.
Raws li lub hauv paus ntawm nws cov nyhuv antitumor, cell tuag yog kho los ntawm gasdermin protein, uas txhawb kev tsim pore. Cov protein no txhawb kev ua kom thiab nkag mus ntawm lub cev tiv thaiv kab mob los ntawm kev tso cov cytokines proinflammatory thiab cov tshuaj tiv thaiv kab mob tom qab cell rupture. Txawm li cas los xij, xav txog nws qhov xwm txheej, kev tuag ntawm tes tsis zoo kuj tseem cuam tshuam txog kev tsim cov qog txhawb microenvironment. Yog li ntawd, kev nkag siab tob txog txoj hauv kev molecular ntawm cell scorch tuag thiab kev nkag siab meej txog kev sib raug zoo ntawm cell scorch tuag thiab mob qog noj ntshav yuav pab peb siv tag nrho cov cell scorch tuag thiab siv rau cov tswv yim tiv thaiv kab mob uas twb muaj lawm lossis tshiab. .
Cov ntsiab lus
Raws li ib hom ntawm inflammatory cell tuag, pyrosis plays lub luag hauj lwm tseem ceeb hauv qog inhibition los ntawm stimulating antitumor tiv thaiv kab mob. Qee zaum, qhov yooj yim ntawm tes tuag induction yuav txaus los cuam tshuam cov qog loj hlob. Txawm li cas los xij, ib qho ntawm cov teeb meem loj tshaj plaws rau kev siv cov kev kho mob cell tuag yog qhov tsis sib xws ntawm kev qhia thiab kev ua haujlwm ntawm cov cell tuag ntsig txog cov khoom, uas tsis yog tsuas yog muaj nyob hauv cov qog nqaij hlav sib txawv, tab sis kuj nyob rau tib hom mob qog noj ntshav. Txawm li cas los xij, kev nce qib hauv molecular, genetic thiab epigenetic lub hom phiaj / kev xa tawm, nrog rau kev txhim kho cov tshuaj raug thiab tus kheej, muab peb cia siab tias yuav siv cov cuab yeej muaj zog no los ua cov cuab yeej kho mob qog noj ntshav sai sai.
