Cov qog muaj ntau lab tus kabmob kheesxaws, thiab nws txoj kev loj hlob tuaj yeem nyob hauv ntau qhov chaw hauv lub cev kom ua rau lub zog ntawm cov qauv ib puag ncig. Nws suav nrog kev txhim kho random los ntawm qhov nws pib. Vim tias cov hlab ntsha loj nrog cov phab ntsa muaj zog thiab cov ntaub so ntswg tuab xws li pob txha mos yog feem ntau nyuaj rau loj tuaj mus ua qog, cov qog feem ntau loj tuaj raws"" ;.
Lub sijhawm no, nws txhais tau tias cov qog ntshav tau tsim mus rau qhov mob qog nqaij hlav cancer tiag tiag, uas yog, mob qog nqaij hlav, uas txhais tau tias cov qog nqaij hlav cancer tau txeem los ntawm qhov chaw uas lawv tshwm sim rau qhov chaw tob dua. Kev txhawm rau mob cancer, qhov tseem ceeb ua rau mob cancer tuag yog qhov zoo ntawm kev mob qog nqaij hlav metastasis. Raws li kev txheeb cais, 90% ntawm kev tuag mob yog los ntawm metastasis. Nws yog qhov nyuaj los kho tus mob cancer metastatic, thiab mob ntsws yog qhov ua pob hlav metastasis nyob hauv chaw kho mob.
Kev tshawb nrhiav pom tias cov qog nqaij hlav cancer nyiam" npaj" rau kev mob cancer metastasis. Piv txwv, ua ntej lub tsiv teb tsaws ntawm ntsws mob metastasis, qee qhov kev mob qog cytokines tau hloov mus rau lub ntsws cov ntaub so ntswg" qhib thaj chaw thiab nthuav av"
Chen Gen: los ntawm mob qog mus rau mob cancer metastasis, cov tshuaj tiv thaiv kab mob hauv lub cev ua phooj ywg
Tsis tas li ntawd, nyob rau hauv kev cuam tshuam ntawm cov qog, lub cev yuav tseem npaj cov myeloid mus rau hauv cov ntaub so ntswg lub ntsws. Piv txwv, hematopoietic qia hlwb thiab hematopoietic progenitor hlwb hauv cov hlwb pob txha qog cov kabmob ua kom cov leeg loj tuaj, thiab lawv nkag mus rau lub ntsws ua ntej cov qog qog thiab txawv mus rau hauv cov tshuaj tiv thaiv myeloid hlwb.
Raws li qhov no, pab pawg coj los ntawm xibfwb Rosandra Kaplan ntawm National Cancer Institute ntawm Tebchaws Meskas (NCI) tau sim hloov lub hlwb myeloid, thiab tso tawm cov lus qhia tawm tsam mob qog noj ntshav mus rau mob qog nqaij hlav hloov chaw los ntawm kev siv cov yam ntxwv ntawm lawv yooj yim los sau cov khoom noj khoom haus ua ntej metastasis, thiab yog li ua tiav ntev lub sij hawm mob cancer metastasis inhibition nyhuv.
Cov kws tshawb nrhiav tau pib nrog IL-12, ib qho ntawm cytokines tsim tawm los ntawm myeloid cov hlwb. Feem ntau, thaum kis tus mob thiab cov qog tshwm sim, cov hlwb myeloid yuav tsim IL-12, ua kom lub hlwb T thiab cov kab mob tua neeg (NK) hlwb, txhim kho IFN γ cov tshuaj tiv thaiv, nce kev nthuav qhia antigen thiab txo cov angiogenesis. Ntawd yog, cov hlwb myeloid tuaj yeem pab lub cev tua cov mob qog nqaij hlav cancer, tab sis nyob rau hauv cov lus tawm tsam, nws tiv thaiv lub cev tiv thaiv kab mob thiab txhawb ntxiv kev mob qog nqaij hlav metastasis.
Yog li cov kws tshawb nrhiav tau txiav txim siab forcibly txhim kho lub peev xwm ntawm myeloid hlwb los khaws lub IL-12 thiab rov ua nws lub peev xwm tiv thaiv kev mob qog noj ntshav. Thaum lub sijhawm sim, cov kws tshawb nrhiav tau siv cov yam ntxwv ntawm myeloid cov hlwb los sib sau ua ke tau yooj yim rau cov qog thiab cov chaw metastasis, thiab hloov kho rau cov pa kom ntau dhau ntawm IL-12. Lawv hu qhov hloov myeloid hlwb IL 12 lub pov haum.
Cov txiaj ntsig tau pom tias cov qog metastasis tau raug muab zais thiab cov qog hauv situ poob hauv cov qog cov kabmob ua cov nas kho nrog lub pov haum. Tsis tas li ntawd, cov kws tshawb nrhiav pom tias gemys zais IL-12 hauv situ thiab pre metastasis niche, nrhiav thiab qhib cov qog ua haujlwm tiv thaiv qog, thiab thim rov qab cov immunosuppressive microenvironment ntawm pre metastasis niche.
Hauv cov kev tshawb fawb ntxiv, cov kws tshawb nrhiav ua ke gemys nrog kev kho mob, nqaij hlav, lossis T-cell immunotherapy, uas qhia muaj teeb meem loj antitumor. Tshwj xeeb tshaj yog ua ke nrog kev siv tshuaj kho mob (cyclophosphamide), kev mob qog tau tswj hwm tau ntev lawm (lub qog yuav tsis rov mob ntau dua 100 hnub tom qab kev kho mob).
Cov mob kheesxaws metastasis yog qhov ua kom ntau tus neeg mob cancer tuag. Los ntawm kev tawm tsam kev siv rau kev tiv thaiv txee - kev dag, mob qog noj ntshav thiab mob qog nqaij yuav tsum muaj kev ua si ntev ntev. Yog tias" txee tawm kev cuam tshuam" ntawm kev mob kheesxaws metastasis tuaj yeem pom tau sai li sai tau, nws tseem yuav coj ntau txoj hauv kev los kho mob qog noj ntshav.
